Effect of Family History on Treatment Response in Alopecia Areata Patients
DOI:
https://doi.org/10.63666/ejsmr.1694-9013.4.I.2026.94Keywords:
Family history, Treatment response, Alopecia AreataAbstract
Objective: The aim of the present study was to assess the effect of family history on treatment response in alopecia areata patients. Methodology: This analytical cross-sectional study was carried out among 60 patients attending Dr. Lina's Skin and Aesthetics center, Dhaka within the defined period from January 2026 to March 2026. Permission was taken from the Administrative Head of the Dr. Lina's Skin and Aesthetics center authority to collect data. Purposive sampling was done according to availability of the patients. Informed written consent was taken from each Participant. Privacy and confidentiality was maintained strictly. The collected data were entered into the computer and analyzed by using SPSS (version 20.1). Patient diagnosed with alopecia areata by qualified Dermatologists will be enrolled for the study. Result: In our study 11.67 % alopecia areata patients give positive family history and most of the patients (88.33%) family history was negative. Patients with a positive family history had significantly poorer treatment responses (28.6% vs 66.0% achieving >50% regrowth, p=0.046). Patients with positive family history showed poor responses to both treatments (Fractional CO2 Laser and Intralesional steroid injection), suggesting these subgroups may benefit from alternative or combination therapeutic approaches. Conclusion: Patients with a positive family history had significantly poorer treatment responses suggesting family history as an independent prognostic factor.
References
1.Raghda Atef Abd Elshafy, Naglaa Ali Khalifa, Rasha Mohamed Besher, & Mahmoud. (2022). Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article. The Egyptian Journal of Hospital Medicine, 88(1), 2897–2903. https://doi.org/10.21608/ejhm.2022.242771
2. Łukasik, A., Kozicka, K., Kłosowicz, A., Jaworek, A., & Wojas-Pelc, A. (2020). The role of family history and its influence on the onset time in female pattern hair loss. Advances in Dermatology and Allergology. https://doi.org/10.5114/ada.2020.100745
3. Alopecia areata: An update. (2013, August 31). Indian Journal of Dermatology, Venereology and Leprology. https://ijdvl.com/alopecia-areata-an-update
4. Wang, S., Ratnaparkhi, R., Piliang, M., & Bergfeld, W. F. (2018). Role of family history in patchy alopecia areata. Dermatology Online Journal, 24(10), 13030/qt0n19r7ps.
5. Engin, B., Oba, M. Ç., & TüzünY. (2017). Alopecia Areata. Hair and Scalp Disorders. https://doi.org/10.5772/66594
6. Vestergaard, C., Daniel, Randeep Mandla, Frøstrup, A. G., Gren, S. T., Petri Vänni, Anna-Kaisa Asikainen, Kofoed, K., & Cato Mørk. (2025). Alopecia Areata: Impact on Patients’ Quality of Life and Disease Perception: A Survey-Based Study. Acta Dermato Venereologica, 105, adv43318adv43318. https://doi.org/10.2340/actadv.v105.43318
7. Gilhar, A., Etzioni, A., & Paus, R. (2012). Alopecia Areata. New England Journal of Medicine, 366(16), 1515–1525. https://doi.org/10.1056/nejmra1103442
8. Redler, S., F Buket Ü Basmanav, Blaumeiser, B., Bartels, N. G., Lutz, G., Aylar Tafazzoli, Kruse, R., Wolff, H., Böhm, M., Blume-Peytavi, U., Becker, T., Nöthen, M. M., & Betz, R. C. (2017). Parent-of-origin Effect in Alopecia Areata: A Large-scale Pedigree Study. Acta Dermato Venereologica, 97(7), 862–863. https://doi.org/10.2340/00015555-2658
9. Arousse, A., Boussofara, L., Mokni, S., Gammoudi, R., Saidi, W., Aounallah, A., Belajouza, C., Ghariani, N., Denguezli, M., & Nouira, R. (2019). Alopecia areata in Tunisia: epidemio‐clinical aspects and comorbid conditions. A prospective study of 204 cases. International Journal of Dermatology, 58(7), 811–815. https://doi.org/10.1111/ijd.14381
10. Brzezińska-Wcisło, L., Bergler-Czop, B., Wcisło-Dziadecka, D., & Lis-Święty, A. (2014). New aspects of the treatment of alopecia areata. Advances in Dermatology and Allergology/Postȩpy Dermatologii I Alergologii, 31(4), 262–265. https://doi.org/10.5114/pdia.2014.40923
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